先科新覺 晚期攝護腺癌新療法 可降...

晚期攝護腺癌新療法 可降低死亡率40%

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【新三才訊】美國腫瘤學會(American Society for Clinical Oncology)3日在芝加哥召開年會,會上針對攝護腺癌發表的兩項研究報告指出,為晚期攝護腺癌的標準療法加上一種新的抗荷爾蒙藥物,可使死亡率降低40%。

「法新社」報導,這種藥物是楊森藥廠(Janssen)製造的阿比特龍(abiraterone),品牌名為澤珂(Zytiga)。

攝護腺癌有92%在癌細胞尚未擴散到身體其他部分的早期即發現,可是約有5%患者確診時癌細胞已擴散,平均存活期不到5年。

轉移性攝護腺癌的標準治療藥物是潑尼松(predinisone),而涵蓋34國的1200名患者的研究顯示,如合併使用阿比特龍,死亡風險可降低38%,癌症惡化的時間也從14.8個月延長到33個月。

第二項涵蓋將近2000名男性的臨床試驗顯示,在晚期患者的初步標準療法加入阿比特龍,可使死亡風險降低37%,癌症復發的機率也降低70%,骨頭出現嚴重併發症的機率則降低50%。

服用阿比特龍的患者更容易出現嚴重副作用,尤其是高血壓之類的心血管問題,以及肝臟分泌酵素異常。

在第一項研究,使用合併療法的患者有20%出現高血壓,比標準療法的10%高出一倍。在第二項研究有41%患者出現嚴重副作用,高於標準療法的29%。

研究人員說,這顯示屬於心臟問題高風險群的男性,例如糖尿病患,對使用阿比特龍必須特別慎重。

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